Biologic treatments for asthma are specialized therapies aimed at patients with severe, uncontrolled asthma, typically initiated after confirming diagnosis, checking adherence to existing high-dose treatments, and identifying specific inflammatory markers (biomarkers).
Biologics can offer significant reductions in asthma attacks and steroid use by targeting specific inflammatory pathways (IgE, IL-5, or IL-4/IL-13).
The key criteria for accessing biologics generally involve demonstrating high disease burden and specific inflammatory phenotypes.
Key Eligibility Criteria
· Severe Asthma Diagnosis: Patient must have severe, persistent asthma that is uncontrolled despite optimal high-dose inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA).
· High Exacerbation Rate: Frequent asthma attacks, usually defined as 3–4 or more within the past 12 months, requiring oral corticosteroid (OCS) tablets or emergency hospital visits.
· OCS Dependence: Patients who are on continuous or regular long-term oral steroids.
· Biomarker Profiles: Type 2 Inflammation (eosinophilic and allergic asthma) and non-type 2 inflammation normal level of eosinophils and biologic treatment for non-type 2 inflammation stops your airways reacting as much to triggers.
· Allergic Asthma: Elevated IgE levels with positive skin/serum testing for perennial aeroallergens.
· Eosinophilic Asthma: High blood eosinophil count.
· FeNO Elevation: High fractional exhaled nitric oxide.
· Comorbidities: Presence of type-2 related comorbidities such as chronic rhinosinusitis with nasal polyps (CRSwNP) or atopic dermatitis, which can be affected by the choice of biologic.
· Adherence and Technique Check: Before approval, specialists must verify that the patient is taking their current medication correctly and has the correct inhaler technique.
· Age and Other Conditions: Different biologics have age restrictions, usually 6+ or 12+ years old. Other comorbidities like nasal polyposis or atopic dermatitis can be key selection factors.
Biologics Available: Mepolizumab (Nucala), Benralizumab (Fasenra), Omalizumab (Xolair and Omlyclo), Dupilumab (Dupixent) Tezepelumab (Tezspire).
The effectiveness of Biologics: Significant reduction in exacerbations, improved quality of life, and steroid-sparing effects (reducing the need for oral corticosteroids).
Some common side effects (affecting up to 1 in 10 people) include:
· Headache
· Sinus pain
· Sore throat
· soreness at the injection site. This should go away in a few days and may improve after you’ve had the injection a few times.
· Sometimes biologic treatments for asthma can increase the risk of a severe allergic reaction (anaphylaxis) for some people. The risk is rare (1 in 1000) and more likely if you have a history of allergic reactions or anaphylaxis.
Biologics are a specialist, targeted treatment. They are a ‘Add on treatment’ that are used in conjunction with your current asthma medication.
There are strict criteria for who can access them. You need to be referred to a specialist severe asthma service before you can be considered for biologic treatments. If you are suitable for your clinician will discuss your suitability and discuss the next steps which include a local multidisciplinary team meeting (MDT) and a regional Birmingham Regional Severe (MDT). The MDT meeting outcomes are made known either via a respiratory consultant or by clinical nurse specialist.
A Clinical Nurse Specialist (CNS) role in asthma biologics manages the care pathway for severe asthma patients, assessing eligibility, initiating treatment, and monitoring outcomes. They provide education on self-administration, monitor for adverse effects, and work within multidisciplinary teams (MDTs) to improve quality of life and reduce exacerbations.
Patient Assessment & Selection: Evaluate patients with severe asthma to determine eligibility for biologic therapies, reviewing blood tests, eosinophil counts, and asthma control levels.
Education & Support: Educate patients, families, and carers on asthma management, inhaler techniques, and the use of biologic medication which is supported with biologic patient information literature. Travel advice can also be provided.
Administration & Monitoring: Administer biologic via a sub-cut pre-filled injection in clinic, supervise self-administration training for home use, and conduct follow-up spirometry tests, eosinophil blood test and assessments to monitor treatment efficacy and safety.
Multidisciplinary Team Working (MDT): Collaborate with consultants, nurses, and pharmacists to manage patient care, including attending specialist MDT meetings and with the patient your General practitioner (GP).
Service Development & Audit: Participate in clinical audits, data submission to the National Asthma Audit Programme (NACAP), and developing protocols for the severe asthma service.
Pregnancy: If are planning a pregnancy or are currently pregnant and you’re using biologics or wish to be considered for biologic treatment you should speak with your specialists or midwife to be guided for more advice.
Improved Patient Outcomes: CNS roles are linked to reduced hospital admissions and better management of severe asthma through targeted therapies.
Our adult asthma service works with our paediatric service for patient’s established on biologics to streamline the patient care transitioning into our adult asthma services.